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Dr. David Rabago Establishes the University of Wisconsin Prolotherapy Education & Research Lab (UW PEARL)

Since 2004, the Hackett Hemwall Patterson Foundation hosts an annual HHPF  Prolotherapy Research Symposium (usually in October) at the University of Wisconsin, Madision.  This meeting brings together clinicians, clinical researchers and basic scientists interested in prolotherapy research and related injection therapies to present completed or ongoing studies with the goal of facilitating a high level of understanding of current research in treating musculoskeletal conditions and chronic pain and to stimulate further work among and between researchers, clinicians and other attendees.

In 2005, Dr. David Rabago, a colleague of Dr. Jeff Patterson, and a family medicine physician and researcher formerly at the University of Wisconsin, Madision, established the Univeristy of Wisconsin Prolotherapy Education and Research Lab (UW PEARL) to promote prolotherapy research, education and collaboration with national and international colleagues. Dr. Rabago is now faculty at Penn State Unniversity. We have fortunate to have him as past president of the HHP Foundation.

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Additional Studies

  • R. Sit,R.Keung Wu,D. Rabago,K. D. Reeves,D. Chan,B. Yip,V.ChungandS. Wong, Efficacy of Intra-Articular Hypertonic Dextrose (Prolotherapy) for Knee Osteoarthritis: A Randomized Controlled TrialThe Annals of Family MedicineMay2020,18(3)235-242

  • Bertrand H, Reeves KD, Bennett CJ, Bicknell S, Cheng AL. Dextrose Prolotherapy Versus Control Injections in Painful Rotator Cuff Tendinopathy. Arch Phys Med Rehabil. 2016 Jan;97(1):17-25

  • Louw WF, Reeves KD, Lam SKH, Cheng AL, Rabago D. Treatment of Temporomandibular Dysfunction With Hypertonic Dextrose Injection (Prolotherapy): A Randomized Controlled Trial With Long-term Partial Crossover. Mayo Clin Proc. 2019 May;94(5):820-832.

  • F. Hassan, et al. The effectiveness of prolotherapy in treating knee osteoarthritis in adults: A systematic review. British Medical Bulletin, 2017, 122:91–108​

  • Wang, J., Liang, J., Yao, al. Meta-analysis of clinical trials focusing on hypertonic dextrose prolotherapy (HDP) for knee osteoarthritis. Aging Clin Exp Res 34, 715–724 (2022).

  • Waluyo Y, Artika SR, Insani Nanda Wahyuni, Gunawan AMAK, Zainal ATF. Efficacy of Prolotherapy for Osteoarthritis: A Systematic Review. J Rehabil Med. 2023 Feb 27;55


  • Rabago D, Ralston B, Zaharoff A.Prolotherapy: An Evidence-Based Adjunctive Therapy for Knee Osteoarthritis. Am Fam Physician. 2021 Apr 1;103(7):395. Letter to the Editor

  • Lane Anderson et al., Effectiveness and safety of prolotherapy injections for management of lower limb tendinopathy and fasciopathy: A systematic review, J of Foot and Ankle Research,vol 8, Article number: 57 (2015)

  • Lucrezia Tognolo, Anna Scanu, Claudia Vargiu, ManueleLucangeli, Stefano Masiero, Dextrose prolotherapy for chronic tendinopathy: A scoping review, European Journal of Integrative Medicine, Volume 56,2022

  • Goh S-L, Jaafar Z, Gan Y-N, Choong A, Kaur J, Kundakci B, etal. (2021), Efficacy of prolotherapy in comparison to other therapies for chronic soft tissue injuries: A systematic review and network meta-analysis.

  • Mengting Z., Rabago D., Chung V., Reeves K., Wong Y.,Sit R., Effects of Hypertonic Dextrose Injection (Prolotherapy) in Lateral Elbow Tendinosis: A Systematic Review and Meta-analysis, Archives of Physical Medicine and Rehabilitation, Vol 103, Issue11, 2022

  • Sit, R.W.S., Wu, R.W.K., Ling, al. A protocol for a randomized clinical trial assessing the efficacy of hypertonic dextrose injection (prolotherapy) in chronic ankle instability.Trials 23, 1063 (2022).

  • E. Johnston, Y. Kou, J.Junge, L. Chen, A.Kochan,M. Johnston,D. Rabago, Hypertonic Dextrose Stimulates Chondrogenic Cells to Deposit Collagen and Proliferate. Cartilage. Vol13,Issue2_suppl(2021)

  • Pan, Po-Junga,b; Wang, Jia-Chib,c; Tsai, Chih-Chund;Kuo, Hsing-Chune,f, Identification of early response to hypertonic dextrose prolotherapy markers in knee osteoarthritis patients by an inflammation-related cytokine array. Journal of the Chinese Medical Association 85(4):p 525-531, April 2022

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Hackett Hemwall Paterson Foundation is a Tax Exempt 501 (c)3 organization as approved by the Internal Revenue Service. Accordingly Contributions to the Foundation are fully deductible subject to any limitations that apply to your tax situation. 

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